tributyrin intravenous

  • Inhibition of histone deacetylase on ventricular

     · VPA, tributyrin, and theophylline had little effect on cardiac gross morphology in the sham-operated rats, Plasma pharmacokinetics of tributyrin after intravenous administration of sodium tributyrin or oral administration of tributyrin or sodium tributyrin to mice and rats. Cancer Chemother Pharmacol 43 445–453, 1999.

  • An investigation on the use of tributyrin nanoemulsions

     · When injected intravenously into mice as a nanoemulsion, the docetaxel/tributyrin combination displayed extreme toxicity. Therefore, the current data preclude its combination with docetaxel in nanoemulsions for intravenous administration.

  • Tributyrin induces differentiation, growth arrest and

     · Tributyrin is an active differentiating and cytotoxic agent available for clinical testing in human prostate cancer. Here we report for the first time that tributyrin, like butyric acid, has differentiating and cytotoxic effects and induces cell cycle arrest as well as apoptosis in 3 phenotypic and genotypic divergent human prostate cancer cell lines.

  • Preparation and Characterization of Tributyrin Sub

     · Tributyrin (10%) o/w emulsion containing paclitaxel (5%), egg phosphatidylcholine (5%) and pegylated phospholipid (0.5%) was prepared by high pressure homogenization to obtain sub-micron-sized emulsion. The mean particle size of the resultant TB

  • Tributyrin Just The Ingredient For Product Development

     · Tributyrin (TB) is a triglyceride based on glycerol which has three attached butyrate groups. As in all triglycerides, the attachment of the butyric acid group is via an ester bond. It is a compound naturally found in butter and is used to make margarine. The compound is also highly stable and taken as an absorbed prodrug for butyric acid.

  • Dietary tributyrin, an HDAC inhibitor, promotes muscle

     · Tributyrin provides an efficient means to deliver butyrate to systemic circulation for a sustained duration (Egorin et al. 1999). Our results indicate that butyrate may act as a molecular signal, with a direct effect on satellite cell myogenesis. Our primary objective was to determine the effect of tributyrin supplementation on muscle growth at

  • Preparation and evaluation of tributyrin emulsion as a

     · Treatment with tributyrin emulsion suppressed the colony formation of melanoma cells in a dose-dependent manner. Furthermore, after intraperitoneal administration into mice, tributyrin emulsion inhibited the forma-tion of tumor colonies in the lung following intravenous injection of melanoma cells. Taken together, our data

  • Oral administration of tributyrin increases concentration

     · Second, tributyrin has a half-life of approximately 40 min, with more favorable pharmacokinetic properties, and is better tolerated when compared with intravenous butyrate solution.22, 23 Third, a direct effect on the liver by the higher hepato-portal butyrate level could be expected following oral administration.23, 24 Finally, we hypothesized that orally administered tributyrin would be absorbed

  • Clinical and pharmacologic study of tributyrin an oral

    Tributyrin (NSC) was supplied by the National Cancer Institute, Cancer Therapy Evaluation Program. Drug was supplied as white, soft gelatin capsules containing 500 mg of tributyrin without additives. Drug treatment Cohorts of at least three patients were entered at each dose level, as previouslydescribed[2].Asnodose

  • Butyrate, a metabolite of intestinal bacteria, enhances

     · Oral gavage administration of tributyrin. Oral gavage administration of tributyrin at the beginning of the dark phase elicited robust sleep responses in mice (Fig. 1, Table 1).In the first four

  • Clinical and pharmacologic study of tributyrin An oral

    Previously our group demonstrated that daily oral administration of the prodrug, tributyrin, is able to briefly achieve levels > 100 μM. Given in vitro data that differentiating activity requires continuous butyrate exposure, the short t1/2 of the drug and a desire to mimic the effects of an intravenous infusion, we evaluated a three times daily schedule.

  • Nanostructured lipid carriers loaded with tributyrin as an

    Nanostructured lipid carriers loaded with tributyrin as an alternative to improve anticancer activity of all-trans retinoic acid. Silva EL(1), Carneiro G, Caetano PA, Goulart G, Ferreira Costa D, de Souza-Fagundes EM, Gomes DA, Ferreira LA.

  • Fat emulsions for complete intravenous nutrition

    intravenous fat emulsions were published in the AmericanJournalofClinical Nutrition in 1965. Afat emulsion for intravenous nutrition usually contains a vegetable oil in water and one or two emulsifiersto stabilize theemulsion. Alargenumber of fats or triglycerides have been studied during recent years. The five commercial fat emulsions,

  • Oral administration of tributyrin increases concentration

     · Second, tributyrin has a half-life of approximately 40 min, with more favorable pharmacokinetic properties, and is better tolerated when compared with intravenous butyrate solution.22, 23 Third, a direct effect on the liver by the higher hepato-portal butyrate level could be expected following oral administration.23, 24 Finally, we hypothesized

  • Clinical and pharmacologic study of tributyrin an oral

     · Tributyrin is a prodrug of butyrate and overcomes many of the problems of the parent compound. It is a triglyceride containing three butyrate molecules esterified to glycerol (Fig. 1 ). Most importantly, the drug can be administered orally.

  • Tributyrin Abstracts 1tahomaclinic

     · Tributyrin, a triglyceride with butyrate molecules esterified at the 1, 2, and 3 positions, induces differentiation and/or growth inhibition of a number of cell lines in vitro. When given p.o. to rodents, tributyrin produces substantial plasma butyrate concentrations.

  • 7 Butyrate Benefits Side Effects & SourcesSelfHacked

     · Tributyrin is a novel prodrug of butyrate that is found in milk fat and honey Tributyrin was able to destroy cancer cells in patients with advanced solid tumors [96, 97]. At least two more butyrate-containing preparations with anti-cancer activity have been or are currently being tested

  • Tributyrin Supplementation Protects Immune Responses and

     · Tributyrin is a structured lipid with 3 butyrate molecules esterified to glycerol. M. J. Egorin, Z. M. Yuan, D. L. Sentz, K. Plaisance, and J. L. Eiseman, "Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats," Cancer Chemotherapy and

  • 7 Butyrate Benefits Side Effects & SourcesSelfHacked

     · Tributyrin is a novel prodrug of butyrate that is found in milk fat and honey Tributyrin was able to destroy cancer cells in patients with advanced solid tumors [96, 97]. At least two more butyrate-containing preparations with anti-cancer activity have been or are currently being tested

  • Tributyrin attenuates obesity-associated inflammation and

     · the chronic low-grade inflammation associated with obesity plays a central role as a link between excessive fat accumulation and the development of pathologies ().In obesity, adipose tissue is markedly infiltrated by proinflammatory macrophages and other leukocytes that secrete proinflammatory cytokines and chemokines (20, 41, 50).The overproduction of these inflammatory mediators together

  • Tributyrin, a Stable and Rapidly Absorbed Prodrug of

     · Tributyrin was also a more potent growth inhibitor than either (OH) 2 D 3 alone or butyrate over time, i.e., after 48–120 h of treatment, tributyrin (1 mmol/L) reduced Caco-2 cell growth by 22–53% compared with 8–15% for (OH) 2 D 3 alone (1 μmol/L) and 11–23% for butyrate (2 mmol/L).

  • Preparation and evaluation of tributyrin emulsion as a

    Furthermore, after intraperitoneal administration into mice, tributyrin emulsion inhibited the formation of tumor colonies in the lung following intravenous injection of melanoma cells. Taken together, our data suggests that tributyrin emulsion may be developed as a potent anti-cancer agent against melanoma.

  • tributyrin Semantic Scholar

    A triglyceride prodrug of butyric acid with potential antineoplastic activity. Butyrate, the active metabolite of tributyrin, inhibits histone deacetylase, resulting in increased differentiation, decreased proliferation, cell cycle arrest, and apoptosis in some tumor cell lines. (NCI04)

  • Fat emulsions for complete intravenous nutrition

    intravenous fat emulsions were published in the AmericanJournalofClinical Nutrition in 1965. Afat emulsion for intravenous nutrition usually contains a vegetable oil in water and one or two emulsifiersto stabilize theemulsion. Alargenumber of fats or triglycerides have been studied during recent years. The five commercial fat emulsions,

  • An investigation on the use of tributyrin nanoemulsions

     · An investigation on the use of tributyrin nanoemulsions for docetaxel delivery. Tributyrin, an oil with anticancer properties, is a good solubilizer for docetaxel, an agent used in the treatment of several cancers. In this paper, the interaction between tributyrin and docetaxel was investigated in vitro in search of a potential synergistic effect.

  • (PDF) Intravenous dosing conditions may affect systemic

    A simplified liquid chromatography assay intravenous administration of ATRA loaded into tributyrin for the quantitation of halofantrine and desbutylhalofantrine submicron emulsion and its cellular activity on caco-2 and in plasma and identification of a degradation product of des- HepG2 cell lines.

  • Tributyrin C15H26O6PubChem

    NCI Thesaurus (NCIt) Tributyrin is a triglyceride obtained by formal acylation of the three hydroxy groups of glycerol by butyric acid. It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor, a protective agent, an apoptosis inducer, a prodrug and an antineoplastic agent.

  • Plasma pharmacokinetics of butyrate after intravenous

    Methods Female CD2F1 mice were treated with tributyrin by oral gavage or with sodium butyrate by i.v. bolus or oral gavage. Oral tributyrin doses delivered to mice were 3.1, 5.2, 7.8, and 10.3 g/kg. Intravenous sodium butyrate doses were 0.31, 0.62, 0.94, and 1.25 g/kg. Oral sodium butyrate was given to mice at 5 g/kg.

  • Effects of dietary tributyrin on intestinal mucosa

     · tributyrin (provided by Shanghai Menon Feed Co. Ltd., Shanghai, China). The formula for the diets is in compliance with NRC (2012) (Table 1). Pigs had free to drink and feed. Sample collection After 14days, 6 pigs (3 barrows and 3 gilts) from each treatment (1 pig per pen) were euthanized with an ear intravenous injection of sodium

  • Tributyrin attenuates obesity-associated inflammation and

     · Plasma pharmacokinetics of butyrate after intravenous administration of sodium butyrate or oral administration of tributyrin or sodium butyrate to mice and rats. Cancer Chemother Pharmacol 43 445–453, 1999. Crossref PubMed ISI Google Scholar 9. Fock RA , Vinolo MA , Crisma AR , Nakajima K , Rogero MM , Borelli P.

  • Dietary supplementation with tributyrin alleviates

    Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid Yongqing Hou1*, Lei Wang1, Dan Yi1, Binying Ding1, Xing Chen1, Qingjing Wang1, Huiling Zhu1, Yulan Liu1, Yulong Yin1, Joshua Gong2 and Guoyao Wu3 1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Changqing Garden,

  • Dipotassium hydrogen phosphate K2HPO4PubChem

    . Dipotassium hydrogen phosphate is a potassium salt that is the dipotassium salt of phosphoric acid. It has a role as a buffer. It is a potassium salt and an inorganic phosphate. Potassium Phosphate, Dibasic is the dipotassium form of phosphoric acid, that can be used as an electrolyte replenisher and with radio-protective activity.

  • 7 Butyrate Benefits Side Effects & SourcesSelfHacked

     · Tributyrin is a novel prodrug of butyrate that is found in milk fat and honey Tributyrin was able to destroy cancer cells in patients with advanced solid tumors [96, 97]. At least two more butyrate-containing preparations with anti-cancer activity have been or are currently being tested